Kyle Gillett

Kyle Gillett, MD, is a dual board-certified physician in family medicine and obesity medicine and an expert in hormone optimization for both men and women. He practices full-spectrum medicine, including hormone health, preventive medicine, obstetrics, and pediatrics, from a clinic in Kansas and via telemedicine.

Products they talk about

Betaine👍 Recommends
…explaining betaine as alternative for creatine non-responders
“Another one we can loop in with creatine is betaine. Some people are non-responders to creatine. So you can increase that to 10 grams or you can use its cousin, betaine, to help with amino acid synthesis and shunting of energy. One to three grams. In fact, several versions of creatine have betaine mixed in because it helps with the processing of methionine and homocysteine.”
on Huberman Lab
Black Pepper Extract💬 Mentioned
…discussing how black pepper extract may inhibit DHT conversion in men
“Yeah, turmeric, black pepper extract. Do you recommend that people avoid curcumin and turmeric for that reason? If someone's DHT is already low or if they have somewhat insensitive androgen receptor via genetics or via lifestyle, then I recommend they avoid bioavailable curcuminoids like bioavailable turmeric, black pepper extract.”
on Huberman Lab
Boron👍 Recommends
…recommending boron supplementation to lower sex hormone binding globulin
“Let's also mention boron. So if you have a very high SHBG, boron can acutely help lower it, usually in a dose of 5 to 12 milligrams per day. It's not really a sustained effect, but boron is depleted in soils. In many countries, I believe it's very high in soils in Greece and Turkey. So eating dates or raisins that are from those areas potentially have more boron.”
on Huberman Lab
Creatine👍 Recommends
…discussing creatine supplementation for testosterone optimization
“Let's mention creatine as the first one. Creatine is interesting because it has multiple different effects. It helps with amino acid synthesis. It also helps with oxidative stress. It can also serve as the backup fuel tank for your mitochondria, so kind of holding backup ATP. And it does slightly increase total testosterone, and it also increases the conversion of testosterone to dihydrotestosterone.”
on Huberman Lab
Fadogia Agrestis👍 Recommends
…discussing Fadogia agrestis supplementation for natural testosterone elevation
“We can talk about Fadogia next. Fadogia is interesting because it's a genus of plants. Fadogia agrestis is one of them. That species is likely the most well-studied and it will increase LH. It increases the release of luteinizing hormone from the pituitary. That's a hormone that binds to the Leydig cell to the LH receptor kind of like HCG does and it will increase the release of testosterone. The safe dose was an average of 300 milligrams a day. Another regimen that I have people take is 600 milligrams every other day or 600 milligrams three times a week.”
on Huberman Lab
L-Carnitine💬 Mentioned
…discussing L-carnitine supplementation forms, dosing, and bioavailability
“When you inject it, of course, at the supervision of your doctor, it's usually done intramuscularly. It's an aqueous solution. Usually I recommend for oral L-carnitine between 1,000 milligrams and up to 4,000 or 5,000 milligrams. So one to four, maybe even five grams. If you're on that much, especially if you have a dysregulated gut microbiome, you should be concerned with TMAO. L-carnitine potentially has localized effects if you inject it. If you ingest it orally, then it has a very low bioavailability, maybe only 10%.”
on Huberman Lab
Tongkat Ali (Longjack)👍 Recommends
…discussing Tongkat Ali supplementation for testosterone production
“We can talk about things that affect the steroidogenesis cascade. So we could touch on Tongkat Ali. Also known as Long Jack, and that upregulates several different enzymes in the steroidogenesis cascade. Anywhere from 300 to 1,200 milligrams a day. With Tongkat, you need to be careful with the standardization because if you're thinking about a general Tongkat supplement, which is by far the most well-studied, then you're looking at the uricominone content, which is a plant compound that is likely the main active pharmacologic effect.”
on Huberman Lab
Turmeric💬 Mentioned
…discussing how turmeric supplements may inhibit DHT conversion in men
“Yeah, turmeric, black pepper extract. Do you recommend that people avoid curcumin and turmeric for that reason? If someone's DHT is already low or if they have somewhat insensitive androgen receptor via genetics or via lifestyle, then I recommend they avoid bioavailable curcuminoids like bioavailable turmeric, black pepper extract.”
on Huberman Lab
Vitamin D3👍 Recommends
…discussing vitamin D supplementation for testosterone optimization
“Let's briefly mention vitamin D, which is also a hormone. It's actually a sterol hormone. And if you have deficient vitamin D and you replace it, then you will optimize your testosterone. Vitamin D3, I'm guessing you're talking about vitamin D3 specifically when you say vitamin D.”
on Huberman Lab