Metformin
Mentioned 3 times across 3 shows · first heard Sep 2025 on Huberman Lab.
The general take
Thaïs Aliabadi sees metformin as an effective way to improve insulin sensitivity, though she notes it does come with side effects like nausea or diarrhea that patients typically adjust to over time. She positions it as a stronger option compared to supplements, which she says have no side effects, making metformin worth the trade-off for better insulin control.
Who said what
- DS
David Sinclair👍 Recommends
…drug pulsed for longevity benefits and mTOR pathway activation
“Another good one is metformin. Metformin has been shown to make athletes and bodybuilders and people who go to the gym weightlifters do less repetitions... Taking it every other day, I think is better. And particularly if you like to work out, don't take the metformin a few hours before you work out, take it after, or maybe skip it that day.”
The Diary Of A CEO with Steven Bartlett — David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!at 42:28 - TA
Thaïs Aliabadi👍 Recommends
…treating insulin resistance with prescription medication for PCOS management
“There's prescription medication, metformin. What does metformin do? Metformin makes us insulin sensitive. Anything that makes you insulin sensitive, again, lowers that insulin. Are there any side effects to either of them? So the supplements don't have any side effects. Metformin does have side effects, but patients get used to it. The most common side effect with metformin is nausea or diarrhea.”
On Purpose with Jay Shetty — WORLD’S TOP OBGYN Dr. Aliabadi: The #1 Hormone Problem Affecting Millions of Women (And The 4 Changes That Can Reverse It)at 20:04 - MS
Michael Snyder💬 Mentioned
…diabetes medication for blood glucose regulation via insulin sensitivity
“And in terms of muscle mass and a touch in strength as well. I do – again, my hemoglobin A1C isn't too bad. But I don't like losing that much. I'll be honest with you. I thought I looked a little gaunt. So actually I'm now backing off on the Mongero. I don't do it every week like you're supposed to. I'm on the lowest though. So I'm a great responder there. And by the way, when you get in these drug responses, it turns out I'm metformin, non-responder. I did try that early on.”
Huberman Lab — Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyderat 38:59
Listener reviews
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